Maleic Acid → HCID 178484157, 화합물

HRID 51607

반응식

HRID 51607 반응식
[CH3:1][N:2]([CH3:37])[C@@H:3]1[CH2:7][CH2:6][N:5]([C@@H:8]2[CH2:13][CH2:12][C@H:11]([N:14]3[C:18]4[N:19]=[CH:20][N:21]=[C:22]([NH2:23])[C:17]=4[C:16]([C:24]4[CH:29]=[CH:28][C:27]([O:30][C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)=[CH:26][CH:25]=4)=[CH:15]3)[CH2:10][CH2:9]2)[CH2:4]1.[C:38]([OH:45])(=[O:44])/[CH:39]=[CH:40]\[C:41]([OH:43])=[O:42]>C(O)C>[C:38]([OH:45])(=[O:44])/[CH:39]=[CH:40]\[C:41]([OH:43])=[O:42].[C:38]([OH:45])(=[O:44])/[CH:39]=[CH:40]\[C:41]([OH:43])=[O:42].[C:38]([OH:45])(=[O:44])/[CH:39]=[CH:40]\[C:41]([OH:43])=[O:42].[CH3:1][N:2]([CH3:37])[C@@H:3]1[CH2:7][CH2:6][N:5]([C@@H:8]2[CH2:13][CH2:12][C@H:11]([N:14]3[C:18]4[N:19]=[CH:20][N:21]=[C:22]([NH2:23])[C:17]=4[C:16]([C:24]4[CH:25]=[CH:26][C:27]([O:30][C:31]5[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=5)=[CH:28][CH:29]=4)=[CH:15]3)[CH2:10][CH2:9]2)[CH2:4]1

참가 물질

4

반응물 2

HCID 444266Maleic AcidHCID 178484155HCID 178484155, 화합물

생성물 1

HCID 178484157HCID 178484157, 화합물수율 109.9%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A mixture of 4-[4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexanone (100 g, 2.51 mmol), (3R)-(+)-3-(dimethylamino)pyrrolidine (0.86 g, 7.5 mmol), and acetic acid (0.43 mL, 7.5 mmol) in 1,2-dichloroethane (45 mL) was stirred at ambient temperature under an atmosphere of nitrogen for 30 minutes. Sodium triacetoxyborohydride (0.689 g, 3.26 mmol) was added and the mixture stirred at ambient temperature for 22 hours. Water (50 mL) and sodium bicarbonate (1.35 g, 16.1 mmol) were added and the mixture was stirred for 3 hours. The reaction mixture was transferred to a separatory funnel and the organic layer was separated. The aqueous layer was extracted with CH2Cl2(20 mL), and the combined organic extracts were dried over magnesium sulfate, filtered, and the solvent removed under reduced pressure to yield a red oil. The cis and trans isomers were purified by flash chromatography on silica gel (1 L 5% MeOH in CH2Cl2, then 1 L 10% MeOH in CH2Cl2, 1 L 20% MeOH in CH2Cl2, 1 L 30% MeOH in CH2Cl2, 1 L 40% MeOH in CH2Cl2, and 1 L 50% MeOH in CH2Cl2) to yield cis-7-{4-[(3R)-3-(dimethylamino)tetrahydro-1H-1-pyrrolyl]cyclohexyl}-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine as a pink solid (0.558 g, 1.12 mmol) and trans-7-{4-[(3R)-3-(dimethylamino)tetrahydro-1H-1-pyrrolyl]cyclohexyl}-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine as a pink solid (0.210 g, 0.422 mmol). The cis-7-{4-[(3R)-3-(dimethylamino)tetrahydro-1H-1-pyrrolyl]cyclohexyl}-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (0.330 g, 0.670 mmol) was dissolved in warm ethanol (5 mL) then maleic acid (0.233 g, 2.01 mmol) in ethanol (5 mL) was added. The mixture was cooled to ambient temperature and the solid was collected by filtration and dried to give cis-7-{4-[(3R)-3-(dimethylamino)tetrahydro-1H-1-pyrrolyl]cyclohexyl}-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trimaleate salt (0.622 g) as a beige solid: 1H NMR (d6 DMSO, 400 MHz): δ H 8.20(1H, s), 7.41-7.48(4H, m), 7.35(1H, s), 7.08-7.19 (5H, m), 6.45(2H, bs), 6.16(6H, s), 4.70(1H, m), 4.30(2H, bs), 3.80(1H, bs), 3.08(3H, m), 2.76(6H, s), 2.00-2.21(6H, m), 1.74-1.72(4H, m); RP-HPLC (Delta Pak C18, 5 μm, 300 A, 15 cm; 5%-85% acetonitrile-0.1M ammonium acetate over 20 min, 1 mL/min) Rt 13.94 min. MS: MH+ 497.

후처리

  1. filtrationthe solid was collected by filtration
  2. customdried

출처 및 근거

ORD 기록
ord-ef52544270834cb6b16e52af17720437
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713474B2

연결된 노트

불러오는 중…