Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 516105생성일: 2026년 10월 26일
N,N-Diisopropylmethylamine → (R)-methyl 2-(4-chloro-2-(2,4-dimethoxybenzyl)-7-fluoro-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)-4-methylpentanoate
https://huagongshe.com/reaction/516105
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N,N-Diisopropylmethylamine | HCID 547370 | — |
| 반응물 | Leucine methyl ester hydrochloride | HCID 2723695 | — |
| 반응물 | 4,6-dichloro-2-[(2,4-dimethoxyphenyl)methyl]-7-fluoro-1H,2H,3H-pyrrolo[3,4-c]pyridin-3-one | HCID 58317575 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | (R)-methyl 2-(4-chloro-2-(2,4-dimethoxybenzyl)-7-fluoro-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)-4-methylpentanoate | HCID 58317585 | — |
반응 단계
A mixture of 4,6-dichloro-2-(2,4-dimethoxybenzyl)-7-fluoro-1H-pyrrolo[3,4-c]pyridin-3(2H)-one (3 g, 8.08 mmol), (S)-methyl 2-amino-4-methylpentanoate hydrochloride (2.94 g, 16.16 mmol), and N-isopropyl-N-methylpropan-2-amine (3.76 mL, 24.25 mmol) in ACN (50 mL) was stirred at 100° C. for 3 d. The solvent was removed and the resulting residue was used in the next step without further purification. [M+H] calc'd for C23H27ClFN3O5, 480; found, 480.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09108970B2 |
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| 출처 데이터셋 | uspto-grants-2015_08 |
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| ORD ID | ord-f841ab9bc87148b4adf520ab514a5b35 |
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| 출처 메모 | uspto-grants-2015_08 |
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