Dimethylformamide → HCID 178472577, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylformamide	HCID 6228	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
반응물	(2R,4R)-4-amino-5-(3'-chlorobiphenyl-4-yl)-2-hydroxypentanoic acid ethyl ester	HCID 86682253	—
반응물	HCID 178481916	HCID 178481916	—
생성물	HCID 178472577	HCID 178472577	27.3%

반응 단계

5-Hydroxy-1-methyl-1h-pyrazole-3-carboxylic acid (122 mg, 862 μmol) and HATU (361 mg, 949 μmol) were combined in DMF (1.0 mL, 13 mmol) and stirred for 10 minutes. (2R,4R)-4-amino-5-(3′-chlorobiphenyl-4-yl)-2-hydroxypentanoic acid ethyl ester (30.0 mg, 86 μmol) and DIPEA (165 μL, 949 μmol) were added, and the resulting mixture was stirred at room temperature overnight. The mixture was then concentrated under reduced pressure and the residue was dissolved in 50% AcOH-water (1.5 mL), filtered, purified by reverse phase preparative HPLC, and lyophilized to yield the title compound (11.1 mg). MS m/z [M+H]+ calc'd for C24H26ClN3O5, 472.16. found 472.2.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09108934B2
출처 데이터셋	uspto-grants-2015_08
ORD ID	ord-a1e22c1b7ca94f548df0a5cbf19ac39c
출처 메모	uspto-grants-2015_08