Hydrazine, 1-naphthalenyl- → 3-(4-Bromo-phenyl)-1,5-di-naphthalen-1-yl-1H-[1,2,4]triazole

HRID 516496

반응식

HRID 516496 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:12][C:13]([C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][CH:16]=2)=O)OCC)=[CH:4][CH:3]=1.[C:25]1([NH:35][NH2:36])[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=[CH:27][CH:26]=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:13]([C:15]3[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH:18]=[CH:17][CH:16]=3)[N:35]([C:25]3[C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH:28]=[CH:27][CH:26]=3)[N:36]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 75240Hydrazine, 1-naphthalenyl-HCID 57610336Naphthalene-1-carboxylic acid 1-(4-bromo-phenyl)-1-ethoxy-methylideneamide

생성물 1

HCID 576103533-(4-Bromo-phenyl)-1,5-di-naphthalen-1-yl-1H-[1,2,4]triazole

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

반응 조건

온도
25 °C

실험 절차

The compound obtained in step A) (1.0 g, 0.026 mol) and 1-naphthyl hydrazine (0.45 g, 0.028 mol) is dissolved in CCl4 (15 ml) and stirred for 10 hours at 25° C. under a nitrogen atmosphere. The reaction mixture is stirred for 12 hours and filtered to remove traces of insoluble particles. The CCl4 solution is then concentrated and a few drops of methanol are added to the residue, wherein a brownish solid is obtained (Yield=0.7 g (56%)).

후처리

  1. stirringThe reaction mixture is stirred for 12 hours
  2. filtrationfiltered
  3. customto remove traces of insoluble particles
  4. concentrationThe CCl4 solution is then concentrated
  5. additiona few drops of methanol are added to the residue, wherein a brownish solid
  6. customis obtained (Yield=0.7 g (56%))

출처 및 근거

ORD 기록
ord-d7c2db3732134b1683088925a9ff0fc8
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09113536B2

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