3-methyl-N-(1-methylethyl)-2-nitrobenzamide → 2-amino-3-methyl-N-(1-methylethyl)benzamide

HRID 516499

반응식

HRID 516499 반응식
[CH3:1][C:2]1[C:3]([N+:14]([O-])=O)=[C:4]([CH:11]=[CH:12][CH:13]=1)[C:5]([NH:7][CH:8]([CH3:10])[CH3:9])=[O:6].[H][H]>C(O)C.[Pd]>[NH2:14][C:3]1[C:2]([CH3:1])=[CH:13][CH:12]=[CH:11][C:4]=1[C:5]([NH:7][CH:8]([CH3:10])[CH3:9])=[O:6]

참가 물질

5

반응물 2

HCID 8902723-methyl-N-(1-methylethyl)-2-nitrobenzamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 167760932-amino-3-methyl-N-(1-methylethyl)benzamide수율 96.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The 2-nitrobenzamide of Step A (1.70 g, 7.6 mmol) was hydrogenated over 5% Pd/C in 40 mL of ethanol at 50 psi. When the uptake of hydrogen ceased the reaction was filtered through Celite® diatomaceous filter aid and the Celite® was washed with ether. The filtrate was evaporated under reduced pressure to afford 1.41 g of the title compound as a solid melting at 149-151° C.

후처리

  1. filtrationwas filtered through Celite® diatomaceous filter aid
  2. washthe Celite® was washed with ether
  3. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-5aeaad0e7e8942e2a98a4bff28aa9c59
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09113630B2

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