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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 517032생성일: 2026년 10월 25일

5-Cyanopyridine-2-carboxylic acid → N-{3-[(4r,5r)-2-Amino-5-Fluoro-4-Methyl-5,6-Dihydro-4h-1,3-Oxazin-4-Yl]-4-Fluorophenyl}-5-Cyanopyridine-2-Carboxamide

https://huagongshe.com/reaction/517032

반응식

참여 물질

역할이름HCID투입량
반응물5-Cyanopyridine-2-carboxylic acidHCID 12400734—
반응물(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 86672004—
생성물N-{3-[(4r,5r)-2-Amino-5-Fluoro-4-Methyl-5,6-Dihydro-4h-1,3-Oxazin-4-Yl]-4-Fluorophenyl}-5-Cyanopyridine-2-CarboxamideHCID 66558601—

반응 단계

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 5-cyano-pyridine-2-carboxylic acid (CAS 53234-55-2) following procedure I yielded the title compound as a crystalline white solid. MS (ISP): m/z=372.2 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09115098B2
출처 데이터셋uspto-grants-2015_08
ORD IDord-a62911431c77428babcaf8d81c17c900
출처 메모uspto-grants-2015_08