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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 517036생성일: 2026년 10월 26일

3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid → 3-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

https://huagongshe.com/reaction/517036

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참여 물질

역할이름HCID투입량
반응물3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acidHCID 2821908—
반응물(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 86672004—
생성물3-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amideHCID 66558686—

반응 단계

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid (CAS 80194-68-9) following procedure I yielded the title compound as a white foam. MS (ISP): m/z=449.1 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09115098B2
출처 데이터셋uspto-grants-2015_08
ORD IDord-505a502f00dc4d9aa17f8857c75751ed
출처 메모uspto-grants-2015_08