2,5-Dimethyl-3-furoic acid → 2,5-Dimethyl-furan-3-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

HRID 517048

반응식

HRID 517048 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:17])=[C:6]([C@:8]2([CH3:16])[C@@H:13]([F:14])[CH2:12][O:11][C:10]([NH2:15])=[N:9]2)[CH:7]=1.[CH3:18][C:19]1[O:20][C:21]([CH3:27])=[CH:22][C:23]=1[C:24](O)=[O:25]>>[NH2:15][C:10]1[O:11][CH2:12][C@H:13]([F:14])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:24]([C:23]3[CH:22]=[C:21]([CH3:27])[O:20][C:19]=3[CH3:18])=[O:25])[CH:3]=[CH:4][C:5]=2[F:17])([CH3:16])[N:9]=1

참가 물질

3

반응물 2

HCID 694652,5-Dimethyl-3-furoic acidHCID 86672004(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

생성물 1

HCID 665591892,5-Dimethyl-furan-3-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

실험 절차

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 2,5-dimethyl-furan-3-carboxylic acid (CAS 636-44-2) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=364.3 [M+H]*.

출처 및 근거

ORD 기록
ord-147682f71ffb47509853f342b80bae78
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115098B2

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