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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 517069생성일: 2026년 10월 27일

3-Chloro-5-cyanopyridine-2-carboxylic acid → 3-Chloro-5-cyano-pyridine-2-carboxylic acid [3-((4R,5S)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

https://huagongshe.com/reaction/517069

반응식

참여 물질

역할이름HCID투입량
반응물3-Chloro-5-cyanopyridine-2-carboxylic acidHCID 50853176—
반응물(4R,5S)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 86672005—
생성물3-Chloro-5-cyano-pyridine-2-carboxylic acid [3-((4R,5S)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amideHCID 66558860—

반응 단계

The condensation of (4R,5S)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.1) and 3-chloro-5-cyano-pyridine-2-carboxylic acid following procedure I yielded the title compound as an off-white foam. MS (ISP): m/z=406.2 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09115098B2
출처 데이터셋uspto-grants-2015_08
ORD IDord-f2e74413a26a4d8e9242f2b518498148
출처 메모uspto-grants-2015_08