Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Ethynyl-1-(1-isopropoxycyclopropyl)-3-methyl-benzene → Ethyl4-[4-(1-isopropoxycyclopropyl)-3-methyl-phenylethynyl]-benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Ethynyl-1-(1-isopropoxycyclopropyl)-3-methyl-benzene | HCID 22568997 | — |
| 반응물 | Ethyl-4-iodo-benzoate benzoate | HCID 69887287 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | Ethyl4-[4-(1-isopropoxycyclopropyl)-3-methyl-phenylethynyl]-benzoate | HCID 22568844 | 159.2% |
반응 단계
Using General Procedure F; 4-ethynyl-1-(1-isopropoxycyclopropyl)-3-methyl-benzene (Intermediate 81, 80.0 mg, 0.13 mmol) and ethyl-4-iodo benzoate (Reagent A, 100.0 mg, 0.36 mmol) in triethylamine (5 mL) was treated with copper(I)iodide (25.0 mg, 0.13 mmol) and sparged with argon for 5 minutes. Dichlorobis(triphenylphosphine)-palladium(II) (91 mg, 0.13 mmol) was added and the reaction mixture was stirred overnight at room temperature. Column chromatography (2-4% EtOAc-hexanes) afforded 75.0 mg (56%) of the title compound as an orange solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713647B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-8fadf66058e54861ba260ff04d8d7272 |
| 출처 메모 | uspto-grants-2004_03 |