Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenecarboximidamide, 4-hydroxy-, hydrochloride (1:1) → 3-[5-(4-Amidinophenoxycarbonyl)thiophen-2-yl]-2-methylpropenoic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenecarboximidamide, 4-hydroxy-, hydrochloride (1:1) | HCID 217124 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 5-(2-(tert-Butoxycarbonyl)-1-propenyl)-2-thiophenecarboxylic acid | HCID 77478494 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 3-[5-(4-Amidinophenoxycarbonyl)thiophen-2-yl]-2-methylpropenoic acid tert-butyl ester | HCID 86673317 | 86.3% |
반응 단계
5-(2-(tert-Butoxycarbonyl)-1-propenyl)-2-thiophenecarboxylic acid (0.51 g, 1.89 mmol) and 4-hydroxybenzamidine hydrochloride (0.33 g, 1.89 mmol) were dissolved in pyridine (10 mL), WSC hydrochloride (0.54 g, 2.8 mmol) was added, and the mixture was stirred overnight. The mixture was purified by high performance liquid chromatography and freeze-dried to give the title compound (0.63 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09115107B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-cc29a6b81db1469dabc7c771c1072f24 |
| 출처 메모 | uspto-grants-2015_08 |