Trifluoroacetic acid → (2E)-3-[5-(benzyloxycarbonyl)furan-2-yl]-2-propenoic acid

HRID 517336노트

반응식

HRID 517336 반응식
[CH2:1]([O:8][C:9]([C:11]1[O:12][C:13]([CH:16]=[CH:17][C:18]([O:20]C(C)(C)C)=[O:19])=[CH:14][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[CH2:1]([O:8][C:9]([C:11]1[O:12][C:13](/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19])=[CH:14][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 779345505-(2-tert-Butoxycarbonylethenyl)furan-2-carboxylic acid benzyl ester

생성물 1

HCID 70869499(2E)-3-[5-(benzyloxycarbonyl)furan-2-yl]-2-propenoic acid

실험 절차

To 5-(2-tert-butoxycarbonylethenyl)furan-2-carboxylic acid benzyl ester (0.15 g, 0.46 mmol) obtained in Example 41, step 2 was added trifluoroacetic acid (3 mL), and the mixture was stirred for 30 minutes. The solvent was evaporated under reduced pressure to give the title compound.

후처리

  1. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-f491899c07b74235a3fb6af232a38953
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115107B2

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