Methanol → L-cysteic acid methyl ester hydrochloride

HRID 517340

반응식

HRID 517340 반응식
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][S:4](=[O:7])([OH:6])=[O:5].S(Cl)([Cl:13])=O.[CH3:15]O>>[ClH:13].[CH3:15][O:9][C:8](=[O:10])[C@H:2]([CH2:3][S:4](=[O:6])([OH:7])=[O:5])[NH2:1]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 72886L-Cysteic acid

생성물 1

HCID 86673321L-cysteic acid methyl ester hydrochloride수율 75%

실험 절차

L-cysteic acid (300 mg, 1.77 mmol) was dissolved in methanol (12 mL), and thionyl chloride (2.5 mL, 34 mmol) was slowly added at 0° C. After stirring at room temperature overnight, the reaction mixture was concentrated under reduced pressure, and the obtained residue was suspended in diisopropyl ether. The suspension was filtered to give the title compound as white crystals (291 mg, 1.33 mmol, 75%).

후처리

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. filtrationThe suspension was filtered

출처 및 근거

ORD 기록
ord-b64c9b6861254997bd7f20929fefe32b
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115107B2

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