Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium ethoxide → Ethyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Diethyl Maleate | HCID 5271566 | — |
| 반응물 | 3-Hydrazinopyridine | HCID 10909519 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate | HCID 118023220 | — |
반응 단계
In a preferred reaction, sodium ethoxide in an anhydrous ethanol are introduced into a reaction vessel and 3-hydrazinopyridine•dihydrochloride is added. The mixture is stirred and diethyl maleate is added. The mixture is heated at about 60° C. until most of the 3-hydrazinopyridine has reacted. The mixture is allowed to cool and the excess base is neutralized with acid. The crude ethyl 5-oxo-2-(pyridin-3-yl)pyrazolidine-3-carboxylate (10a) is conveniently isolated and purified by standard techniques.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09115115B1 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-42d8946a0a5a4bf3931940a96bca62d0 |
| 출처 메모 | uspto-grants-2015_08 |