Potassium Carbonate → 1-Ethynyl-4-(1-benzyloxycyclopropyl)-3-ethyl-benzene

HRID 51739노트

반응식

HRID 51739 반응식
[CH2:1]([O:8][C:9]1([C:12]2[CH:17]=[CH:16][C:15]([C:18]#[C:19][Si](C)(C)C)=[CH:14][C:13]=2[CH2:24][CH3:25])[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:18]([C:15]1[CH:16]=[CH:17][C:12]([C:9]2([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:11][CH2:10]2)=[C:13]([CH2:24][CH3:25])[CH:14]=1)#[CH:19]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 22568833[4-(1-Benzyloxycyclopropyl)-3-ethyl-phenylethynyl]-trimethylsilane2회

생성물 1

HCID 225689831-Ethynyl-4-(1-benzyloxycyclopropyl)-3-ethyl-benzene

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Using General Procedure E; [4-(1-benzyloxycyclopropyl)-3-ethyl-phenylethynyl]-trimethylsilane (Intermediate 89, 240 mg, 0.69 mmol) in methanol (6 mL) was treated with potassium carbonate (10.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (190 mg, 99%) was used directly in the next reaction. 1H NMR (CDCl3) δ: 7.43-7.15 (8H, m), 4.27 (2H, s), 3.08 (1H, s), 3.01 (2H, q, J=7.6 Hz), 1.26 (3H, t, J=7.6 Hz), 1.22 (2H, m), 0.92 (2H, m).

출처 및 근거

ORD 기록
ord-c2b0bd9ac43442f2906cc1437201cb5b
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713647B2

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