4-Bromophenyl isocyanate → 4-[3-(4-Bromo-phenyl)-ureido]-N,N-dimethyl-benzamide

HRID 517417노트

반응식

HRID 517417 반응식
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]([CH3:10])[CH3:9])=[O:7])=[CH:4][CH:3]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]=[C:21]=[O:22])=[CH:16][CH:15]=1>C(Cl)Cl>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:22])[NH:1][C:2]2[CH:12]=[CH:11][C:5]([C:6]([N:8]([CH3:10])[CH3:9])=[O:7])=[CH:4][CH:3]=2)=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 756094-Bromophenyl isocyanateHCID 2355274-Amino-N,N-dimethylbenzamide

생성물 1

HCID 689172644-[3-(4-Bromo-phenyl)-ureido]-N,N-dimethyl-benzamide수율 88.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-amino-N,N-dimethyl-benzamide (3.5 g, 0.0213 mol), TEA (2.15 g, 0.0213 mol) in DCM (50 mL) was added 4-bromophenyl isocyanate (5.07 g, 0.0256 mol). The reaction mixture was stirred at room temperature for 12 h. The white solid was obtained and was filtered and dried to afford the title compound [6.8 g, 88%]; LC-MS (ESI): Calculated mass: 361.0; Observed mass: 362.0 [M+H]+ (RT: 0.17 min).

후처리

  1. customThe white solid was obtained
  2. filtrationwas filtered
  3. customdried

출처 및 근거

ORD 기록
ord-051ee5daeb974aa1b4af6dc36c889d69
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115092B2

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