Sulfuric Acid → 1H-Indole-2,3-dione, 6-bromo-

반응식

S(=O)(=O)(O)[OH:2].[Br:6][C:7]1[CH:8]=[C:9]([NH:13][C:14](=[O:18])[CH:15]=NO)[CH:10]=[CH:11][CH:12]=1>>[Br:6][C:7]1[CH:8]=[C:9]2[C:10]([C:15](=[O:2])[C:14](=[O:18])[NH:13]2)=[CH:11][CH:12]=1

참가 물질

반응물 2

HCID 1118Sulfuric Acid

HCID 6739944Acetamide, N-(3-bromophenyl)-2-(hydroxyimino)-

생성물 1

HCID 957161H-Indole-2,3-dione, 6-bromo-수율 98%

반응 조건

온도: 90 °C

실험 절차

To the concentrated sulfuric acid (275 mL) at 50° C. was added N-(3-Bromo-phenyl)-2-hydroxyimino-acetamide (55 g, 0.2272 mol). The temperature was raised to 90° C. and maintained for 3 h. The reaction mixture was added to ice cold water to get yellow precipitate. The precipitate was filtered and dried to get the title compound as a yellow solid [50 g, 98%]. This material was taken to the next step without any further purification.

후처리

temperaturemaintained for 3 h
additionThe reaction mixture was added to ice cold water
customto get yellow precipitate
filtrationThe precipitate was filtered
customdried

출처 및 근거

ORD 기록: ord-097cadf1ee1e402d8af8573733d12e98
출처 데이터셋: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09115092B2

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