(Z)-tert-butyl 2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)acetate → (Z)-2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)acetic acid

반응식

[CH2:1]([O:3][C:4]1[CH:25]=[CH:24][C:7](/[CH:8]=[C:9]2/[C:10](=[O:23])[N:11]([CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])[C:12](=[O:14])[S:13]/2)=[CH:6][CH:5]=1)[CH3:2].NCCN1C(=O)C(CC2C=CC(OCC)=CC=2)SC1=O>>[CH2:1]([O:3][C:4]1[CH:25]=[CH:24][C:7](/[CH:8]=[C:9]2/[C:10](=[O:23])[N:11]([CH2:15][C:16]([OH:18])=[O:17])[C:12](=[O:14])[S:13]/2)=[CH:6][CH:5]=1)[CH3:2]

참가 물질

반응물 2

HCID 5958148(Z)-tert-butyl 2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)acetate

HCID 716970713-(2-Aminoethyl)-5-(4-ethoxybenzyl)thiazolidine-2,4-dione

생성물 1

HCID 6302733(Z)-2-(5-(4-ethoxybenzylidene)-2,4-dioxothiazolidin-3-yl)acetic acid수율 93.4%

실험 절차

The title compound 28h was prepared by deprotection of tert-butyl group of compound 28g (300 mg, 0.82 mmol). Deprotection following the procedure of compound 6 gave the title compound 28h as a yellow solid (93.4%, 235 mg).

출처 및 근거

ORD 기록: ord-9b65d6db43ce4f728fc7a325a431f427
출처 데이터셋: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09115122B2

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