Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → 1-(4-Chlorophenyl)-5-[(3,3-difluoro-1-pyrrolidinyl)methyl]-1H-tetrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Chlorophenyl isocyanide | HCID 74670 | — |
| 반응물 | Azidotrimethylsilane | HCID 78378 | — |
| 반응물 | 3,3-Difluoropyrrolidine hydrochloride | HCID 24903482 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-(4-Chlorophenyl)-5-[(3,3-difluoro-1-pyrrolidinyl)methyl]-1H-tetrazole | HCID 68074508 | — |
반응 단계
To a solution of 3,3-difluoropyrrolidine hydrochloride (129 mg, 0.90 mmol, Sigma-Aldrich) in methanol (3 mL) was added formaldehyde (37% aqueous) (0.067 mL, 0.90 mmol) and triethylamine (0.139 mL, 1.00 mmol). The reaction mixture was shaken at room temperature for 2 hours. To the reaction mixture was added 4-chlorophenyl isocyanide (138 mg, 1.00 mmol) and trimethylsilylazide (0.133 mL, 1.00 mmol). The reaction mixture was shaken at room temperature for a further 18 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09115132B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-cd43199020bd453d94a2a1123bc5b8fa |
| 출처 메모 | uspto-grants-2015_08 |