Potassium Carbonate → HCID 61699309, 화합물
반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[CH:9]1([CH2:12][NH2:13])[CH2:11][CH2:10]1.C(=O)([O-])[O-].[K+].[K+].CC(N(C)C)=O>O>[Cl:8][C:4]1[N:3]=[C:2]([NH:13][CH2:12][CH:9]2[CH2:11][CH2:10]2)[CH:7]=[N:6][CH:5]=1참가 물질
6
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of 2,6-dichloropyrazine (2.99 g), 1-cyclopropylmethanamine (2.14 g), potassium carbonate (4.14 g) and DMA (20 mL) was stirred at 80° C. for 23 hr. Water (15 mL) was added, and the mixture was extracted with ethyl acetate. The aqueous layer was extracted again with ethyl acetate. The combined organic layer was washed with water and saturated brine, dried over magnesium sulfate, and concentrated. This was used without purification for the next reaction.
후처리
- extractionthe mixture was extracted with ethyl acetate
- extractionThe aqueous layer was extracted again with ethyl acetate
- washThe combined organic layer was washed with water and saturated brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
- customThis was used without purification for the next reaction
출처 및 근거
- ORD 기록
- ord-1e88ff22095042adab2903571f3a6694
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09115139B2
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