Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5'-Bromo-2'-hydroxyacetophenone → 1'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5'-Bromo-2'-hydroxyacetophenone | HCID 95991 | — |
| 반응물 | 1-Phenyl-4-piperidinone | HCID 413009 | — |
| 반응물 | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| 생성물 | 1'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one | HCID 66932220 | — |
반응 단계
1′-Phenyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one was synthesized according to the procedure for preparation of Intermediate 1, Step A, using 1-phenyl-piperidin-4-one (607 mg, 3.47 mmol) and 2-hydroxy-5-bromoacetophenone (746 mg, 3.47 mmol), giving 650 mg as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09115148B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-c0950ea8371547d0926ea53da7c061be |
| 출처 메모 | uspto-grants-2015_08 |