Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl acrylate → (E)-3-{1-Benzyl-3',4'-dihydro-4'-oxo-spiro[piperidine-4,2'(1'H)-quinazoline]-6'-yl}-acrylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl acrylate | HCID 15458 | — |
| 반응물 | 1-benzyl-6'-bromo-3',4'-dihydro-spiro[piperidine-4,2'(1H)-quinazoline]-4'-one | HCID 46077949 | — |
| 반응물 | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| 생성물 | (E)-3-{1-Benzyl-3',4'-dihydro-4'-oxo-spiro[piperidine-4,2'(1'H)-quinazoline]-6'-yl}-acrylic acid tert-butyl ester | HCID 66932495 | — |
반응 단계
(E)-3-{1-Benzyl-3′,4′-dihydro-4′-oxo-spiro[piperidine-4,2′(1′H)-quinazoline]-6′-yl}-acrylic acid tert-butyl ester was synthesized starting from 1-benzyl-6′-bromo-3′,4′-dihydro-spiro[piperidine-4,2′(1′H)-quinazoline]-4′-one (600 mg, 1.55 mmol) and tert-butyl acrylate according to the procedure described for Intermediate 1, Step B, giving 486 mg of the product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09115148B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-5683ea6afdaa4f3cae33f709d6e8add1 |
| 출처 메모 | uspto-grants-2015_08 |