(2-Methoxy-ethyl)-(4-methoxy-3-nitro-phenyl)-methyl-amine → 4-methoxy-N1-(2-methoxy-ethyl)-N1-methyl-benzene-1,3-diamine
반응식
[CH3:1][O:2][CH2:3][CH2:4][N:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]([N+:15]([O-])=O)[CH:8]=1)[CH3:6]>CO.[Pd]>[CH3:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([N:5]([CH2:4][CH2:3][O:2][CH3:1])[CH3:6])=[CH:8][C:9]=1[NH2:15]참가 물질
4
실험 절차
To a stirred solution of 2.50 g (10.4 mmol) (2-methoxy-ethyl)-(4-methoxy-3-nitro-phenyl)-methyl-amine in 100 ml methanol was added a spatula end of 10% palladium on charcoal and the mixture was then stirred for 16 hours at room temperature under an atmosphere of hydrogen. The mixture was then filtered and the filtrate concentrated in vacuo to afford 1.90 g (87 (ho) 4-methoxy-N1-(2-methoxy-ethyl)-N1-methyl-benzene-1,3-diamine as an off-white crystalline solid. ES-MS m/e (%): 211 (M+H+, 100).
후처리
- filtrationThe mixture was then filtered
- concentrationthe filtrate concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-d8b1b0948c6d4cfbb28598808defdb52
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06713499B2
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