Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl valerate → US10023592, Example 350
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl valerate | HCID 10882 | — |
| 반응물 | Ethyl hexanoate | HCID 31265 | — |
| 반응물 | 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one | HCID 45480194 | — |
| 반응물 | US10023592, Example 134 | HCID 72550334 | — |
| 반응물 | US10023592, Example 146 | HCID 118021343 | — |
| 반응물 | 4-Chloro-2-methylsulfonyl-5-propylpyrimidine | HCID 118021558 | — |
| 반응물 | 5-Butyl-4-chloro-2-methylsulfonylpyrimidine | HCID 118021647 | — |
| 생성물 | US10023592, Example 350 | HCID 118021484 | — |
반응 단계
Examples 351-356 in Table 19 were prepared in a similar multi-step manner as Example 300, step 1 wherein either ethyl pentanoate was converted to 4-chloro-2-methylsulfonyl-5-propylpyrimidine or ethyl hexanoate was converted to 5-butyl-4-chloro-2-methylsulfonylpyrimidine which were then each reacted with a) 3-methoxy-1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-one (described in Example 146, step 3), b) the title compound of Example 98, step 1, or c) 3-chloro-1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-one (described in Example 134) in a manner similar to Example 152, step 5 to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09115114B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-958129c3f413483bbff3763589223c5b |
| 출처 메모 | uspto-grants-2015_08 |