Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → HCID 178454572, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Isobutyric anhydride | HCID 7346 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | HCID 178418966 | HCID 178418966 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178454572 | HCID 178454572 | 99% |
반응 단계
To a solution of tert-butyl cis-4-aminocyclohexylcarbamate (500 mg, 2.333 mmol) in DCM (20 mL) was added isobutyric anhydride (0.407 mL, 2.450 mmol). The solution was stirred overnight at RT. After 16 hours, 4 M HCl in dioxane (2.333 mL, 9.33 mmol) was added, and the reaction was stirred at RT overnight. The resulting white precipitate was collected by vacuum filtration and dried in vacuo to generate N-(cis-4-aminocyclohexyl)isobutyramide hydrochloride as an off-white powder (508 mg, 99% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09115127B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-1b50403a11734cafaf032c6addf143c1 |
| 출처 메모 | uspto-grants-2015_08 |