Hydrochloric Acid → HCID 178454572, 화합물

HRID 518749

반응식

HRID 518749 반응식
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:15])OC(C)(C)C)[CH2:4][CH2:3]1.[C:16](OC(=O)C(C)C)(=O)[CH:17](C)[CH3:18].[ClH:27].O1CCOCC1>C(Cl)Cl>[ClH:27].[NH2:1][C@@H:2]1[CH2:3][CH2:4][C@H:5]([NH:8][C:9](=[O:15])[CH:17]([CH3:18])[CH3:16])[CH2:6][CH2:7]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7346Isobutyric anhydrideHCID 312751,4-DioxaneHCID 178418966HCID 178418966, 화합물

생성물 1

HCID 178454572HCID 178454572, 화합물수율 99%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl cis-4-aminocyclohexylcarbamate (500 mg, 2.333 mmol) in DCM (20 mL) was added isobutyric anhydride (0.407 mL, 2.450 mmol). The solution was stirred overnight at RT. After 16 hours, 4 M HCl in dioxane (2.333 mL, 9.33 mmol) was added, and the reaction was stirred at RT overnight. The resulting white precipitate was collected by vacuum filtration and dried in vacuo to generate N-(cis-4-aminocyclohexyl)isobutyramide hydrochloride as an off-white powder (508 mg, 99% yield).

후처리

  1. waitAfter 16 hours
  2. stirringthe reaction was stirred at RT overnight
  3. filtrationThe resulting white precipitate was collected by vacuum filtration
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-1b50403a11734cafaf032c6addf143c1
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115127B2

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