Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 4-Fluoro-N-{4-methoxy-7-[methyl-(2-oxo-2-piperidin-1-yl-ethyl)-amino]-benzothiazol-2-yl}-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 4-Fluorobenzoic Acid | HCID 9973 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 반응물 | 2-Iodo-1-morpholin-4-yl-ethanone | HCID 11265309 | — |
| 반응물 | 4-Methoxy-1,3-benzothiazole-2,7-diamine | HCID 22736977 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Fluoro-N-{4-methoxy-7-[methyl-(2-oxo-2-piperidin-1-yl-ethyl)-amino]-benzothiazol-2-yl}-benzamide | HCID 22736988 | — |
반응 단계
From 4-methoxy-benzothiazole-2,7-diamine with potassium carbonate and 2-iodo-1-morpholin-4-yl-ethanone in DMF, then treatment with potassium carbonate and iodomethane in DMF, then treatment with 4-fluorobenzoic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 457 (M+H+, 100).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713499B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-7441783e4fed4d589eb82a201d1bfcf7 |
| 출처 메모 | uspto-grants-2004_03 |