HCID 86727380, 화합물 → 1-(5-Amino-2-fluoro-4-hydroxyphenyl)ethanone

HRID 519022노트

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HRID 519022 반응식
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[C:5]([N+:9]([O-])=O)=[CH:4][C:3]=1[C:12](=[O:14])[CH3:13]>CCO.C1COCC1.[Pd]>[NH2:9][C:5]1[C:6]([OH:8])=[CH:7][C:2]([F:1])=[C:3]([C:12](=[O:14])[CH3:13])[CH:4]=1

참가 물질

5

반응물 1

HCID 86727380HCID 86727380, 화합물

생성물 1

HCID 867273811-(5-Amino-2-fluoro-4-hydroxyphenyl)ethanone

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1-(2-fluoro-4-hydroxy-5-nitro-phenyl)-ethanone (3 g, 15.7 mmol) in EtOH (30 mL) and THF (6 mL) was added Pd/C (10%, 1.5 g, 1.4 mmol) and the reaction mixture was stirred at ambient temperature for 2 h. The reaction mixture was filtered and the filtrate was evaporated in vacuo to give 1-(5-amino-2-fluoro-4-hydroxy-phenyl)-ethanone as a black solid (2.5 g, crude), which was used in the next step directly without further purification. 1H-NMR (DMSO-d6, 400 MHz): δ 7.01 (d, J=8.0 Hz, 1H), 6.48 (d, J=12.4 Hz, 1H), 2.39 (d, J=4.8 Hz, 3H).

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated in vacuo

출처 및 근거

ORD 기록
ord-77f013ac6ef244a3bb8f89c026b57da3
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115151B2

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