Isoprene → 1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-5-methyl-
반응식
[C:1]1(=[O:7])[O:6][C:4](=[O:5])[CH:3]=[CH:2]1.[CH2:8]=[CH:9][C:10](=[CH2:12])[CH3:11]>O1CCCC1>[CH3:11][C:10]1[CH2:12][CH:2]2[CH:3]([CH2:8][CH:9]=1)[C:4](=[O:5])[O:6][C:1]2=[O:7]참가 물질
4
실험 절차
A 5-L round bottom reaction flask fitted with a condenser was charged with maleic anhydride (C2H2(CO)2O) (500 g) and tetrahydrofuran (THF) (3 L) and isoprene (CH2═C(CH3)CH═CH2) (400 g) was then added at room temperature. The reaction was mildly exothermic. The reaction mixture was stirred at room temperature for about 2 hours till the Gas Chromatography (“GC”) analysis showed the consumption of maleic anhydride. The resulting mixture containing crude 5-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione was used directly in the next step.
후처리
- customA 5-L round bottom reaction flask fitted with a condenser
- additionwas then added at room temperature
- customthe consumption of maleic anhydride
- additionThe resulting mixture containing crude 5-methyl-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione
출처 및 근거
- ORD 기록
- ord-999d677e6fa64a9eb1ee44d5664f42be
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09115330B2
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