Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanesulfonic acid → (s)-7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-3-carboxylic acid (1-pyridin-2-yl-propyl)-amide ethanesulfonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanesulfonic acid | HCID 11668 | — |
| 반응물 | (s)-7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-3-carboxylic acid (1-pyridin-2-yl-propyl)-amide | HCID 10280962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (s)-7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-3-carboxylic acid (1-pyridin-2-yl-propyl)-amide ethanesulfonate | HCID 131723182 | 102% |
반응 단계
(S)-7-[(4′-Trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-3-carboxylic acid (1-pyridin-2-yl-propyl)-amide (67 mg) was dissolved in 5 ml of ethyl acetate, and ethanesulfonic acid (13 mg, 1 equivalent) was added as a solution in 1.5 ml of ethyl acetate. After 60 min, the mixture was concentrated under vacuum to afford 80 mg of the title compound as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713489B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-306dcd7af0f640b599433594b8b0ed1c |
| 출처 메모 | uspto-grants-2004_03 |