Ethyl 2-[(2'-cyano-3-fluorobiphenyl-4-yl)methyl]-3-oxohexanoate → 3'-Fluoro-4'-{[4-(2-methoxy-1-methylethyl)-2-methyl-5-oxo-7-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl}biphenyl-2-carbonitrile

HRID 519510

반응식

HRID 519510 반응식
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([C:22](=O)[CH2:23][CH2:24][CH3:25])[C:17](OCC)=[O:18])=[C:11]([F:27])[CH:10]=1)#[N:2].[CH3:28][O:29][CH2:30][CH:31]([NH:33][C:34]1[NH:38][C:37]([CH3:39])=[N:36][N:35]=1)[CH3:32]>>[F:27][C:11]1[CH:10]=[C:9]([C:4]2[C:3]([C:1]#[N:2])=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:14]=[CH:13][C:12]=1[CH2:15][C:16]1[C:17](=[O:18])[N:33]([CH:31]([CH3:32])[CH2:30][O:29][CH3:28])[C:34]2[N:35]([N:36]=[C:37]([CH3:39])[N:38]=2)[C:22]=1[CH2:23][CH2:24][CH3:25]

참가 물질

3

반응물 2

HCID 57460949Ethyl 2-[(2'-cyano-3-fluorobiphenyl-4-yl)methyl]-3-oxohexanoateHCID 178495283HCID 178495283, 화합물

생성물 1

HCID 670099643'-Fluoro-4'-{[4-(2-methoxy-1-methylethyl)-2-methyl-5-oxo-7-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl}biphenyl-2-carbonitrile수율 40.3%

반응 조건

온도
250 °C

실험 절차

A mixture of ethyl 2-[(2′-cyano-3-fluorobiphenyl-4-yl)methyl]-3-oxohexanoate (1 g) and N-(2-methoxy-1-methylethyl)-5-methyl-4H-1,2,4-triazol-3-amine (0.25 g) was stirred at 250° C. for 20 min under microwave irradiation. The obtained reaction mixture was purified by silica gel column chromatography to give the title compound as a colorless solid (0.28 g, 40%).

후처리

  1. customThe obtained reaction mixture
  2. customwas purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-e546ee54070746dba1f20f559a60e2f8
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09115136B2

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