Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Acetamide, 2-(hydroxyimino)-N-phenyl-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | Chloral | HCID 6407 | — |
| 반응물 | Isatin | HCID 7054 | — |
| 반응물 | Hydroxylamine HCl | HCID 21645 | — |
| 생성물 | Acetamide, 2-(hydroxyimino)-N-phenyl- | HCID 6861488 | — |
반응 단계
The isatin derivative (9) can be synthesized, for example, as shown in the following reaction scheme. That is, an aqueous solution obtained by adding chloral and hydroxylammonium chloride to hydrochloride of an aniline derivative (10) as a starting material is reacted for 0.5 to 2 hours with heating at 70° to 110° C. to give an isonitrosoacetanilide derivative, and this product is cyclized with concentrated sulfuric acid and hydrolyzed to give an isatin derivative (9). ##STR10## wherein R1A to R1D are as defined above.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05616441 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-e75f94cdfd09486eb81e090e8b1e9b65 |
| 출처 메모 | uspto-grants-1997_04 |