Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 4'-Formyl-2'-nitrobiphenyl-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Bromo-3-nitrobenzaldehyde | HCID 808792 | — |
| 반응물 | 2-Cyano-phenylboric acid | HCID 21708089 | — |
| 촉매 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4'-Formyl-2'-nitrobiphenyl-2-carbonitrile | HCID 86644074 | 47% |
반응 단계
A mixture of 4-bromo-3-nitrobenzaldehyde (10.0 g), 2-cyanophenylboric acid (8.25 g), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), dichloromethane adduct (3.45 g), tetrabutylammonium bromide (1.36 g), 2M aqueous sodium carbonate solution (40 mL) and toluene (400 mL) was refluxed under an argon atmosphere for 3 days. The reaction mixture was concentrated, and the residue was dissolved in ethyl acetate. The obtained ethyl acetate solution was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography to give the title compound as a pale-yellow solid (5.15 g, 40%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09115136B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-19142a26a34e481abc610366d05741bc |
| 출처 메모 | uspto-grants-2015_08 |