Benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate → HCID 19962783, 화합물

HRID 52017노트

반응식

HRID 52017 반응식
[C:1]([N:9]1[C:17]2[CH:16]=[CH:15][C:14]([O:18][C:19]3[N:24]=[C:23]([O:25][CH3:26])[CH:22]=[C:21]([O:27][CH3:28])[N:20]=3)=[C:13]([C:29]([O:31]CC3C=CC=CC=3)=[O:30])[C:12]=2[C:11]([C:39]([O:41][CH2:42][CH3:43])=[O:40])=[C:10]1[CH3:44])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.[C].[Pd]>[C:1]([N:9]1[C:17]2[CH:16]=[CH:15][C:14]([O:18][C:19]3[N:24]=[C:23]([O:25][CH3:26])[CH:22]=[C:21]([O:27][CH3:28])[N:20]=3)=[C:13]([C:29]([OH:31])=[O:30])[C:12]=2[C:11]([C:39]([O:41][CH2:42][CH3:43])=[O:40])=[C:10]1[CH3:44])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 19962759Benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate

생성물 1

HCID 19962783HCID 19962783, 화합물수율 97%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8857Ethyl Acetate용매

실험 절차

1.6 g of benzyl 1-benzoyl-5-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-ethoxycarbonyl-2-methylindol-4-carboxylate was dissolved in 50 ml of ethyl acetate, and 0.1 g of 10% palladium carbon was added thereto. Then, catalytic reduction was conducted. Insoluble matters were filtered off, and then filtrate was concentrated under reduced pressure. The residue thereby obtained was washed with isopropyl ether to obtain 1.28 g (yield: 97%) of the desired compound. mp: 113°-115° C.

후처리

  1. filtrationInsoluble matters were filtered off
  2. concentrationfiltrate was concentrated under reduced pressure
  3. customThe residue thereby obtained
  4. washwas washed with isopropyl ether

출처 및 근거

ORD 기록
ord-842237a3d11e4c5aa8d4605933cc7330
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05616537

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