3-Amino-3-(4-chlorophenyl)propan-1-ol → 4-(4-Chlorophenyl)-N-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

HRID 520243

반응식

HRID 520243 반응식
[NH2:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)[CH2:3][CH2:4][OH:5].[N:13]([C:16]1[CH:21]=[CH:20][C:19]([C:22]2[N:26]=[CH:25][N:24]([C:27]3[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:36])[F:35])=[CH:29][CH:28]=3)[N:23]=2)=[CH:18][CH:17]=1)=[C:14]=S>>[Cl:12][C:9]1[CH:8]=[CH:7][C:6]([CH:2]2[CH2:3][CH2:4][O:5][C:14]([NH:13][C:16]3[CH:17]=[CH:18][C:19]([C:22]4[N:26]=[CH:25][N:24]([C:27]5[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:35])[F:36])=[CH:29][CH:28]=5)[N:23]=4)=[CH:20][CH:21]=3)=[N:1]2)=[CH:11][CH:10]=1

참가 물질

3

반응물 2

HCID 170394353-Amino-3-(4-chlorophenyl)propan-1-olHCID 1185901653-(4-Isothiocyanatophenyl)-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole

생성물 1

HCID 1185901544-(4-Chlorophenyl)-N-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)-5,6-dihydro-4H-1,3-oxazin-2-amine

실험 절차

The title compound was prepared with 3-amino-3-(4-chlorophenyl)propan-1-ol and 3-(4-isothiocyanato-phenyl)-1-(4-trifluoromethoxy-phenyl)-1H-1,2,4-triazole and isolated as an off-white solid (0.150 g, 64%).

출처 및 근거

ORD 기록
ord-68f43543ba9b4ec38d734d024f459c2d
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09326516B2

연결된 노트

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