Ethanolamine → 4(3H)-Quinazolinone, 2-ethyl-3-(2-hydroxyethyl)-

HRID 520285노트

반응식

HRID 520285 반응식
[CH2:1]([C:3]1O[C:7](=[O:9])[C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[N:4]=1)[CH3:2].[CH2:14]([CH2:16][NH2:17])[OH:15]>>[CH2:1]([C:3]1[N:17]([CH2:16][CH2:14][OH:15])[C:7](=[O:9])[C:6]2[C:5](=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 700EthanolamineHCID 9285262-Ethyl-benzo[d][1,3]oxazin-4-one

생성물 1

HCID 103760834(3H)-Quinazolinone, 2-ethyl-3-(2-hydroxyethyl)-

반응 조건

온도
100 °C

실험 절차

1 g of 2-ethyl-4H-3,1-benzoxazin-4-one was added to 10 mL of monoethanolamine and the mixture was heated to 100° C. for 40 minutes. The heating element was then removed and the reaction medium was kept under agitation for about eight hours (end of the reaction). 100 mL were added to the reaction medium and the mixture was extracted with three portions of 25 mL of ethyl acetate. The organic phase was separated, and dried with magnesium sulfate and spin dried, yielding the 2-ethyl-3-(2-hydroxyethyl)quinazoline-4 (3H)-one compound as a yellowish oil, which solidified when left to rest at room temperature, which was used in the next stage, with no purification.

후처리

  1. customThe heating element was then removed
  2. custom(end of the reaction)
  3. addition100 mL were added to the reaction medium
  4. extractionthe mixture was extracted with three portions of 25 mL of ethyl acetate
  5. customThe organic phase was separated
  6. dry with materialdried with magnesium sulfate
  7. customspin dried

출처 및 근거

ORD 기록
ord-7f52c776ce9240d6859264ef7c924bcb
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09326984B2

반응 노트

불러오는 중…