Dimethylformamide → 4-Bromo-2-fluorobenzoyl chloride

HRID 520311노트

반응식

HRID 520311 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([F:11])[CH:3]=1.C(Cl)(=O)C([Cl:15])=O.CN(C=O)C>C(Cl)Cl>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[C:4]([F:11])[CH:3]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 3026814-Bromo-2-fluorobenzoic acid

생성물 1

HCID 27340264-Bromo-2-fluorobenzoyl chloride수율 100.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-bromo-2-fluorobenzoic acid 144a (250 g, 1.14 mol) in dry DCM (2000 mL) was added oxalyl chloride (446 g, 3.51 mol) and DMF (10 mL) at RT, and the reaction mixture was stirred at RT for 1 h. See FIG. 3. The mixture was concentrated under reduced pressure to give 4-bromo-2-fluorobenzoyl chloride 144b (271 g, 100%) as a yellow solid, which was used for the next step without further purification.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-54e8f043908945eba44edd67a3401a95
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09326985B2

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