Phenyltrimethylammonium bromide dibromide → 2-Bromo-1-(4-bromo-2-methylphenyl)ethanone
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([CH3:11])[CH:3]=1.[Br-:12].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1>C1COCC1>[Br:12][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][C:4]=1[CH3:11])=[O:10]참가 물질
4
실험 절차
To a solution of 1-(4-bromo-2-methylphenyl)ethanone (0.525 g, 2.464 mmol) in THF was added phenyltrimethylammonium tribromide (0.926 g, 2.464 mmol). The reaction mixture was stirred at rt for 16 hrs. The reaction mixture was filtered through a plug of diatomaceous earth (Celite®), and the filtrate was concentrated to yield 2-bromo-1-(4-bromo-2-methylphenyl)-ethanone (0.61 g) as a white solid. LC/MS (Cond. N-1): [M+H]+ 290.84, Rt=3.88 min.
후처리
- filtrationThe reaction mixture was filtered through a plug of diatomaceous earth (Celite®)
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-2eb17bfbea9e48c7a7405678ca258b86
- 출처 데이터셋
- uspto-grants-2016_05
- 특허 번호
- US09326973B2
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