HCID 86690121, 화합물 → Methyl 2-(hydroxymethyl)tetrahydrofuran-2-carboxylate

HRID 520416노트

반응식

HRID 520416 반응식
C([O:8][CH2:9][C:10]1([C:15]([O:17][CH3:18])=[O:16])[CH2:14][CH2:13][CH2:12][O:11]1)C1C=CC=CC=1>CO.[Pd]>[OH:8][CH2:9][C:10]1([C:15]([O:17][CH3:18])=[O:16])[CH2:14][CH2:13][CH2:12][O:11]1

참가 물질

4

반응물 1

HCID 86690121HCID 86690121, 화합물

생성물 1

HCID 86690120Methyl 2-(hydroxymethyl)tetrahydrofuran-2-carboxylate수율 178.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

10% Pd—C (80 mg, 0.753 mmol) was added under nitrogen to a solution of methyl 2-((benzyloxy)methyl)tetrahydrofuran-2-carboxylate (377 mg, 1.506 mmol) in MeOH (20 mL) in a Parr shaker bottle and hydrogenated at 30 psi overnight. The suspension was filtered and the filtrate was evaporated to dryness to afford methyl 2-(hydroxymethyl)tetrahydrofuran-2-carboxylate as a clear oil (0.43 g, 97.5%). 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 4.10-3.98 (m, 2H), 3.85 (d, J=11.4 Hz, 1H), 3.78 (s, 3H), 3.69 (d, J=11.4 Hz, 1H), 2.19-2.12 (m, 1H), 2.09-2.02 (m, 1H), 2.01-1.93 (m, 2H).

후처리

  1. filtrationThe suspension was filtered
  2. customthe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-dcac1a5f3a5a49f69855bab980695c17
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09326973B2

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