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1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amine → 6-(6-Fluoro-1-((4-nitrophenyl)sulfonyl)-1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazol-4-amine

HRID 520587
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인쇄 미리보기

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HRID 520587 반응식
[C:1]1([S:7]([N:10]2[C:18]3[CH:17]=[C:16]([Sn](C)(C)C)[CH:15]=[C:14]([NH2:23])[C:13]=3[CH:12]=[N:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[C:25]1[CH:33]=[C:32]([F:34])[CH:31]=[C:30]2[C:26]=1[CH:27]=[CH:28][N:29]2[S:35]([C:38]1[CH:43]=[CH:42][C:41]([N+:44]([O-:46])=[O:45])=[CH:40][CH:39]=1)(=[O:37])=[O:36]>CN(C=O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[F:34][C:32]1[CH:31]=[C:30]2[C:26]([CH:27]=[CH:28][N:29]2[S:35]([C:38]2[CH:39]=[CH:40][C:41]([N+:44]([O-:46])=[O:45])=[CH:42][CH:43]=2)(=[O:36])=[O:37])=[C:25]([C:16]2[CH:15]=[C:14]([NH2:23])[C:13]3[CH:12]=[N:11][N:10]([S:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)(=[O:9])=[O:8])[C:18]=3[CH:17]=2)[CH:33]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 582557431-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amineHCID 583563704-Bromo-6-fluoro-1-[(4-nitrophenyl)sulfonyl]-1H-indole

생성물 1

HCID 672275926-(6-Fluoro-1-((4-nitrophenyl)sulfonyl)-1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazol-4-amine

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매
HCID 6228
Dimethylformamide
용매

반응 조건

온도
120 °C

실험 절차

A mixture of 1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amine (0.8 g), 4-bromo-6-fluoro-1-[(4-nitrophenyl)sulfonyl]-1H-indole (0.879 g) and Pd(PPh3)4 (0.212 g) in DMF (5 ml) was heated at 120° C. for 18 h. The solvent was removed in vacuo and the residue purified by silica cartridge (100 g) using a gradient of cyclohexane and ethyl acetate to give the title compound as an orange solid, 0.42 g.

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue purified by silica cartridge (100 g)

출처 및 근거

ORD 기록
ord-546c6295f29749c88c0feaeba61a9591
출처 데이터셋
uspto-grants-2016_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09326987B2

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