Thionyl Chloride → 1,4-Dimethyl-1H-pyrazole-3-carbonyl chloride

HRID 520597

반응식

HRID 520597 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[C:4]([C:8]([OH:10])=O)=[N:3]1.S(Cl)([Cl:13])=O>>[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[C:4]([C:8]([Cl:13])=[O:10])=[N:3]1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 53256851,4-Dimethyl-1H-pyrazole-3-carboxylic acid

생성물 1

HCID 583563801,4-Dimethyl-1H-pyrazole-3-carbonyl chloride

실험 절차

1,4-Dimethyl-1H-pyrazole-3-carboxylic acid (190 mg) was weighed to a round bottom flask and thionyl chloride (1 ml) was added. The reaction was heated to reflux for 6 h then overnight at RT. After this time thionyl chloride was evaporated and the residue azeotroped with toluene to afford the title compound, 200 mg.

후처리

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 6 h
  3. customovernight
  4. customat RT
  5. customAfter this time thionyl chloride was evaporated
  6. customthe residue azeotroped with toluene

출처 및 근거

ORD 기록
ord-c376dc8ae7c445a988d94f474b950868
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09326987B2

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