Potassium Hydroxide → Potassium 5-chloro-2-fluoro-4-nitrophenolate

반응식

[Cl:1][C:2]1[CH:7]=[C:6](F)[C:5]([F:9])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[OH-:13].[K+:14]>>[Cl:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[CH:4][C:5]([F:9])=[C:6]([O-:13])[CH:7]=1.[K+:14]

참가 물질

반응물 2

HCID 14797Potassium Hydroxide

HCID 101303301-Chloro-4,5-difluoro-2-nitrobenzene

생성물 1

HCID 90016791Potassium 5-chloro-2-fluoro-4-nitrophenolate

실험 절차

A mixture of 1-chloro-4,5-difluoro-2-nitrobenzene (5.12 g, 26.5 mmol) and 15% aqueous KOH (19.9 g) solution was stirred at reflux for 3 hours, then cooled to rt, and filtered to give the title compound as a yellow crystalloid (5.67 g, 93.3%).

후처리

temperatureat reflux for 3 hours
filtrationfiltered

출처 및 근거

ORD 기록: ord-3fb35ed3732e4e43b5745b8e21655155
출처 데이터셋: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09326975B2

반응 노트

불러오는 중…