Dimethylformamide → Acetyl chloride, (4-cyanophenoxy)-

HRID 520833노트

반응식

HRID 520833 반응식
[C:1]([C:3]1[CH:13]=[CH:12][C:6]([O:7][CH2:8][C:9](O)=[O:10])=[CH:5][CH:4]=1)#[N:2].C(Cl)(=O)C([Cl:17])=O.CN(C)C=O>ClCCl>[C:1]([C:3]1[CH:13]=[CH:12][C:6]([O:7][CH2:8][C:9]([Cl:17])=[O:10])=[CH:5][CH:4]=1)#[N:2]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 7360972-(4-Cyanophenoxy)acetic acid

생성물 1

HCID 12207748Acetyl chloride, (4-cyanophenoxy)-

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a suspension of commercially available 2-(4-cyanophenoxy)acetic acid (4.0 g, 22.6 mmol) in dichloromethane (80 mL) was added oxalyl chloride (2.17 mL, 24.8 mmol). To this mixture was added N,N-dimethylformamide (30 μL) dropwise and the mixture was stirred for 2 hours during which cessation of evolution of gas was observed. The resulting solution was diluted with dichloromethane (50 mL) and the solvent was removed under reduced pressure to provide the title compound as an oil which became a solid upon storing in the refrigerator.

후처리

  1. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-00020fe290904569b680f086c2c5b012
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328095B2

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