Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(2-Hydroxyethyl)pyridine → 2-(2-Chloroethyl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(2-Hydroxyethyl)pyridine | HCID 7675 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(2-Chloroethyl)pyridine | HCID 199468 | — |
반응 단계
2-(Pyridin-2-yl)ethanol (1 g, 8.12 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (10 ml) at rt for 3 hrs. The solvent was removed to get a crude 2-(2-chloroethyl)pyridine. Then following General Procedure A, the title compound (1.69 g, 79%) was prepared from 2-amino-4-chlorobenzenethiol (1.6 g, 9.74 mmol), K2CO3 (3.36 g, 24.36 mmol) in DMF (20 ml).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09328067B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-e89e2658e1a74c058d94f6a230341b4f |
| 출처 메모 | uspto-grants-2016_05 |