4-Chloro-3-methylbenzene-1-sulfonyl chloride → 4-chloro-N-[5-chloro-2-(methylthio)phenyl]-3-methylbenzenesulfonamide

HRID 520918

반응식

HRID 520918 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH3:10])=[C:6]([NH2:8])[CH:7]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][C:13]=1[CH3:22]>>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:8][C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[S:9][CH3:10])(=[O:20])=[O:19])=[CH:14][C:13]=1[CH3:22]

참가 물질

3

반응물 2

HCID 2210014-Chloro-3-methylbenzene-1-sulfonyl chlorideHCID 27945775-Chloro-2-(methylthio)aniline

생성물 1

HCID 573786444-chloro-N-[5-chloro-2-(methylthio)phenyl]-3-methylbenzenesulfonamide수율 59.6%

실험 절차

Following General Procedure B, the title compound (205 mg, 59%) was prepared from 5-chloro-2-methylsulfanyl-phenylamine (165 mg, 0.95 mmol) and 4-chloro-3-methyl-benzenesulfonyl chloride (215 mg, 0.95 mmol).

출처 및 근거

ORD 기록
ord-c1a8be0fa57c4bd8a9071dce5dd17d78
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328067B2

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