Benzyl Bromide → 4-Amino-3-(benzylthio)benzonitrile

HRID 520935노트

반응식

HRID 520935 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[SH:10].Br[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[S:10][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 155439364-Amino-3-sulfanylbenzonitrile

생성물 1

HCID 866909904-Amino-3-(benzylthio)benzonitrile수율 79%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Following General Procedure A, the title compound (615 mg, 79%) was prepared from 4-amino-3-mercaptobenzonitrile (486 mg, 3.24 mmol), (bromomethyl)benzene (0.38 ml, 3.24 mmol) and K2CO3 (2.2 g, 16.20 mmol) in DMF (10 ml).

출처 및 근거

ORD 기록
ord-67a458b697184d88a553dbe54147052f
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328067B2

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