Ammonium Chloride → Methyl 2-(((2-amino-5-chlorophenyl)thio)methyl)benzoate

HRID 520984노트

반응식

HRID 520984 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:20]([O-])=O)=[C:6]([S:8][CH2:9][C:10]2[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=2[C:12]([O:14][CH3:15])=[O:13])[CH:7]=1.[NH4+].[Cl-]>CO.C1COCC1.[Zn]>[NH2:20][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][C:6]=1[S:8][CH2:9][C:10]1[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13]

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 86691004Methyl 2-(((5-chloro-2-nitrophenyl)thio)methyl)benzoate

생성물 1

HCID 82976200Methyl 2-(((2-amino-5-chlorophenyl)thio)methyl)benzoate수율 106.9%

시약·촉매·용매 3

HCID 23994Zinc촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

Following General Procedure L, the title compound (158 mg, crude) was prepared from methyl 2-(((5-chloro-2-nitrophenyl)thio)methyl)benzoate (163 mg, 0.48 mmol), Zn (780 mg, 12.0 mmol) and saturated aqueous NH4Cl (10 ml) in MeOH (5 ml) and THF (5 ml). The crude product was used in the next reaction without further purification.

출처 및 근거

ORD 기록
ord-a18d776c880d49c5a18c05ae2c782394
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328067B2

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