Trifluoroacetic acid → (R)-5-methyl-4-(piperidin-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

HRID 521384노트

반응식

HRID 521384 반응식
C(O)(C(F)(F)F)=O.[CH3:8][C@H:9]1[C:17]2[C:16]([CH:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)=[N:15][CH:14]=[N:13][C:12]=2[CH2:11][CH2:10]1>C(Cl)Cl>[CH3:8][C@H:9]1[C:17]2[C:16]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[N:15][CH:14]=[N:13][C:12]=2[CH2:11][CH2:10]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67436185(R)-tert-butyl 4-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperidine-1-carboxylate

생성물 1

HCID 67438320(R)-5-methyl-4-(piperidin-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

TFA (193 μL, 2.50 mmol) was added to a solution of (R)-tert-butyl 4-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperidine-1-carboxylate (32 mg, 0.10 mmol) in DCM (1 mL). The mixture was stirred at room temperature for 1 hour and concentrated to give (R)-5-methyl-4-(piperidin-4-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine as an oil, which was used further without purification.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-02680a540c5542258c58c904e987b969
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328091B2

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