참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Stannous Chloride | HCID 24479 | — |
| 반응물 | 3-(Chlorosulfonyl)-4-methoxybenzoic acid | HCID 3854888 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 3-(5-Carboxy-2-methoxy-phenyldisulfanyl)-4-methoxy-benzoic acid | HCID 12425751 | 99.7% |
반응 단계
45 g (179.5 mmol) of 3-chlorosulfonyl-4-methoxy-benzoic acid were suspended in 200 ml of acetic acid and warmed to 40° C. Then a solution of 85.1 g (448.8 mmol) tin(II) chloride in 100 ml of hydrochloric acid was added within 15 min and the mixture was stirred for 2 h under reflux. The hot solution was added dropwise to 2000 ml of ice/water. The formed precipitate was collected by suction, washed with water and dried. 32.8 g of the title compound were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09328071B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_05 |
|---|
| ORD ID | ord-a3871b5f64654ee9b78d7bffb5787d03 |
|---|
| 출처 메모 | uspto-grants-2016_05 |
|---|
