Dimethylformamide → 4-Chloro-2-ethylsulfanylbenzaldehyde

HRID 521666

반응식

HRID 521666 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4](F)[CH:3]=1.[CH2:11]([SH:13])[CH3:12].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([S:13][CH2:11][CH3:12])[CH:3]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 6343EthanethiolHCID 11430Potassium CarbonateHCID 27249084-Chloro-2-fluorobenzaldehyde

생성물 1

HCID 1148635404-Chloro-2-ethylsulfanylbenzaldehyde

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 4.0 g of 4-chloro-2-fluorobenzaldehyde, 2.05 ml of ethanethiol, 3.82 g of potassium carbonate and 6 ml of DMF was stirred at room temperature for 6 hours, and was allowed to stand overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 3.57 g of 4-chloro-2-ethylsulfanylbenzaldehyde.

후처리

  1. waitto stand overnight
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3ecac01b7d224c75b9a09b7aa985bcb2
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09328121B1

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